EndNote and product data management (PDM) software

I’m trialling the use of EndNote for document creation in our company which will entail using references stored on the internal network. While this is straight forward, in future most of our reference documents are going to be managed by a PDM system, in our case Windchill. They will not be directly visible on a network drive.

Has anyone any experience in this area? Is it necessary to use the API to connect to managed documents?