REFMAN 12 in Citrix Presentation Manager 4.5

I understand that Reference Manager is not officially supported to run in the Citrix/Terminal Services environment, but, that some folks have it running.  I am wondering if anyone would care to share their experiences and any tips that they might have.  We are about to try to create an install in Citrix Presentation Manager 4.5.  

One thing about our server that may be different than yours is that our server has a local drive M instead of a drive C and C instead is a client network map to the client’s local drive.