EndNote 8.1 seriously slow on MacOS 10.13

Thanks but those folders are all with the app in my Applications folder and are not backed up to any cloud service. Right now nothing related to Endnote is backed up/synced to Dropbox yet the app slows down over time and becomes unusable (you know-the status quo these days with Endnote) until and unless I quit ENX8 and restart it. No other app, and I have apps that also are database-driven like Endnote, behaves this way.