Hi fellow Endnote people,
I’m making no guarantees but the following seems to have worked for me:
I am using Endnote X8.01 on a MBP running Mac OSX 10.12 Sierra.
I was having the same problem with Endnote crashing instantly upon clicking the icon. It would eventually start to run if I clicked several times (basically crash/restart/crash/restart/etc) but there was no guarantee it would work on any given day.
Careful reading of the support site reveals that Endnote doesn’t like Cloud-Based services like iCloud and Dropbox. My Endnote library was stored in my Documents folder BUT with Mac OSX Sierra, this folder is automatically uploaded to iCloud.
So - instead of turning off iCloud sync (which I rather like), I moved my Endnote library to my home folder (/Users/XXXXX/EndnoteLibrary.enl) and so far - no problems. I’ve tested it about half a dozen times so far and no crashes.
Anyway - fingers crossed that this fix continues to work and that it helps some of you with your oh-so-frustrating crashes.
best wishes for happy reference-managing