I have the same problem. EndNote X9.3.1 is running very slow on MacOS Catalina 10.15. It takes up to 20 seconds to save a new reference (created manually with an attached PDF file). I have moved my EndNote library, and corresponding PDF files and styles inside the Application folder to prevent these files from synch process to iCloud (backup), but the problem remains. I am in touch with Clarivate support expecting to solve this issue.
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