Endnote X8 + Office 16.10 - No Longer Linking

I would try installing the following version of the CWYW tools instead:

http://download.endnote.com/downloads/plugins/Cite%20While%20You%20Write.dmg

If that does not help then:

Please contact Technical Support directly

1-800-336-4474 option 4 then 1 or

https://support.clarivate.com/Endnote/s/technicalsupport?language=en_US