Endnote and Dropbox: time for marriage counseling?

Those are some good suggestions. You do not want to open the library directly from Dropbox as this can corrupt the library, but saving as a compressed library is fine. If one has EndNote X7, you can consider using the synchronization and library sharing features:

http://endnote.com/kb/122170

http://endnote.com/product-details/library-sharing

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