Guess it depends upon what one means by “compatible.” The design is very windows-like and the tech support with whom I’d communicated some time ago was offering suggestions that didn’t work at all and seemed like they were more attended to the windows side of things. That’s a problem with many applications that start out getting developed by small companies (who tend to be more responsive) then get acquired by large corporations that are more focused on other things. I switched to Bookends which, while not perfect, is extremely reliable and has functions I wished Endnote had had as it would have saved me a lot of time. The developer is extremely responsive and updates are free for two years (and the app costs half or more of what Endnote costs). I dunno, but it was pretty easy to bring over my endnote library and nearly 2,000 attached PDFs.