I use two EndNote 6 databases. One has 6,000 entries and the other has 17,000. I have no speed problems with the smaller database. The larger database is so slow since I switched to EndNote 6 that I am thinking of using Sente instead of EndNote. Sente also has an app which EndNote does not. I do not think EndNote is striving to support Mac users. Simply blaming Apple for problems with EndNote seems unreasonable.