Cannot Edit Bibliography "Document not open"

Are you still experiencing this issue? The first thing I would try would be to reboot the computer. If the issue persists, close all your documents and create a new blank document. See if you can insert a citation and then change the layout of the bibliography in that test document. If that works, try changing the output Style in your document and then change it back before modifying the layout:

http://endnote.com/kb/80893