Dear Tony,
Here a copy of my post to this problem:
Trensofty uses windows 10 pro and word 2016 (O.S. with 64 Bit) but I hope I can help you for this problem.
With all versions of Endnote, it is important to install at first Word (here Word 2016 for Mac) and then EN X9.
In program files please click Configure Endnote/welcome to the EN configuration /Configure EN components.
Restart your computer.
I post an attachment with numbered references on Word 2016. I think that you want such a numbering of your references (Nr. 27-17-18).
In order to obtain the numbering , please follow these steps:
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Select NEJM in Output Styles/Open this style (very small black arrow/click it)
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You ´ll obtain a box like in attachment 10-46-33. You can see Numbered.Click Numbered.
-From Word go to EN X9 and select your references (see 21-17-57)
-Go to Word again and click insert selected citations in Citations.
You must see the same as in my attachment 27-17-18.