It is somewhat browser specific. Sometimes in Chrome, my “open” command means it appears as a box near the bottom right and I still have to open it to import. – while Save, just saves it to the hard drive (usually in “downloads” or it asks where, and you have to browse the folder in explorer it to open it. Sometime you can set browsers to automatically open a file which imports it into endnote (assuming it is the right tagged RIS or endnote ENW filetype). – some publisher sites do the export automatically to endnote, bypassing browser settings.