Can’t say why but if you’re using Windows you can remove the read-only attribute by doing the following:
1. Locate the EndNote library file (.enl), place your cursor on the file name, then right click to display a pop-up menu then select “Properties”.
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This will display the properties window and on the “General” tab, look at the bottom where it says: Attributes. If the “Read-only” box is colored (selected), de-select it by ticking the box.
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Then click the “Apply” button, then the OK button to close the Properties window.