There is a Refman (RIS) export style which I think is part of the default downloaded output styles. At least it lives in my “default” folder. I attach my version.
Also, if this in relation to the Biosketch production, I had posted a question on exporting from endnote for that. I got a response, but they never reached out to me with the perl program. You might try PMing them
http://community.thomsonreuters.com/t5/EndNote-General/Export-from-Endnote-into-My-NCBI-s-My-Bibliography/m-p/127800#M24090
RefMan (RIS) Export.ens (298 KB)